SERVICE

ora™

Repeated implantation failure? Have you checked your personal implantation timing with ora™?

Discover the world’s first blood-based test that identifies your personalized optimal embryo transfer window.
ora™ analyzes microRNAs (miRNA) in the blood using next-generation sequencing (NGS) to determine the endometrium’s receptive period for implantation.

What is the Window of Implantation (WOI)?

The WOI refers to the period within the menstrual cycle when the endometrium is most receptive to embryo implantation. Since this window can vary from person to person, a personalized test is essential.

Non-Invasive

Non-Invasive

Blood-based test (safe and simple)

Single Cycle

Single Cycle

Only one test required

High Accuracy

High Accuracy

More than 95% accuracy
Less than 1% retest rate

Comprehensive Analysis

Comprehensive Analysis

Assessment of 281 miRNA biomarkers

To prevent repeated implantation failure, a personalized embryo transfer (pET) is necessary.
* pET : personalized Embryo Transfer

Why is the ora™ test important?

Around 30% of women have a window of implantation (WOI) that is either earlier or later than average. As a result, implantation may fail even when high-grade embryos are transferred.

Who should consider the ora™ test?

The non-invasive endometrial receptivity analysis is recommended for

  • Anyone who wants to know their personalized optimal embryo transfer window
  • Anyone planning pregnancy quickly due to infertility or advanced maternal age
  • Those who have experienced repeated implantation failure (RIF) of unknown cause
  • Those who have had a chemical pregnancy after embryo transfer
  • Those with only a limited number of high-grade embryos
  • Those who prefer a safe, non-invasive blood test over invasive endometrial biopsy procedures
  • Those who have experienced test failure due to a thin endometrium
  • Those concerned about pregnancy because of high or low body mass index (BMI)

What makes the ora™ test different?

Conventional tissue test ora™ test
Type Invasive Non-invasive
Specimen Endometrial tissue Blood
Biomarkers mRNA (messengerRNA) miRNA (microRNA)
Method qPCR or NGS NGS
Convenience Low High
Specimen collection method
Endometrial biopsy
discomfort, burden, recovery from pain, delayed embryo transfer convenient, simple, no discomfort
Failure rate High (in cases of thin endometrium or insufficient sample) Low (less than 1%)

How are ora™ test results reported?

Endometrial status

Pre-receptive

The blood sample was collected outside the patient’s window of implantation (WOI). The endometrium is not yet ready to receive the embryo.

  • Stage prior to implantation receptivity
  • Low likelihood of implantation after embryo transfer
  • Recommended to delay embryo transfer by 24 hours

Receptive

The blood sample was collected during the patient’s window of implantation (WOI). The endometrium is ready to receive the embryo.

  • Optimal stage for embryo transfer
  • High likelihood of implantation after embryo transfer
  • Embryo transfer can proceed during the receptive window

Post-Receptive

The blood sample was collected outside the patient’s window of implantation (WOI). The endometrium has passed the optimal period for embryo implantation.

① Post-Receptive(Short) : Recommend advancing embryo transfer by 12 hours

② Post-Receptive(Average) : Recommend advancing embryo transfer by 24 hours

  • Inconclusive
  • High possibility of implantation after embryo transfer
  • Embryo transfer is possible during the implantation window

*Inconclusive : ora™ algorithm could not analyze the result data. Re-sampling of the patient’s blood is required.

*Invaild/Insufficient RNA : The RNA quality or concentration of the blood sample was inadequate for ora™ testing. Re-sampling of the patient’s blood is required.

How is the Precision GenoMom test performed?

Sample collection

Blood sample

Transport

Secure delivery by a certified courier service

Testing

Next-generation sequencing (NGS) analysis

Results

Identification of the window of implantation (WOI)

Test Information

Test name Non-invasive endometrial receptivity test (ora™, non-invasive Optimal Receptivity Analysis)
Method Next-generation sequencing (NGS) (NGS, Next Generation Sequencing)
Test items 281 miRNAs
Testing period HRT : Blood draw on Day 4 or Day 5 after progesterone administration Natural Cycle : Blood draw on Day 6 or Day 7 after LH surge or hCG trigger shot
Specimen information Specimen type : Whole blood Volume : 5ml ~ 10ml
Turnaround time 3 weeks (business days)

Precautions and Limitations

  • The ora™ test identifies the individual’s window of implantation (WOI) through genetic analysis. However, ora™ is not a diagnostic test. Since many other factors can influence implantation success or failure, embryo transfer based on ora™ results does not guarantee successful implantation or pregnancy.
  • Test results may vary depending on the sample analyzed, and the results cannot be used for purposes other than those intended. Results are generated according to standard laboratory testing procedures. ora™ results are provided as reference information for clinicians, genetic counselors, or physicians, and cannot be used as a final diagnostic conclusion.
  • Due to individual physiological conditions or other factors, it may not always be possible to obtain blood samples of sufficient quality and quantity for ora™ testing. If this occurs, a new mock cycle and repeat blood draw will be required.
  • In rare cases, such as hemolysis (<2%), re-sampling is necessary.
  • Other rare reasons for re-sampling include: damaged collection tubes, compromised reagents, sample quality issues, cross-contamination between samples, inaccurate clinical information, or technical problems.
  • You should always consult with your healthcare provider to determine whether ora™ testing is appropriate for you. The testing institution is not responsible for any anxiety or psychological concerns that may arise from the test.
  • Blood samples collected for testing are stored at the testing institution for one year after preprocessing. During this period, your biological condition or treatment regimen may change. In such cases, it is strongly recommended to consult your physician first for re-testing.
  • ora™ test results reflect the endometrial status at the time of blood collection. If your treatment type, medication dosage, physical condition, or other medical treatments are adjusted or changed, re-testing is recommended.
LIMS Access Precision GenoMom GenoBro ora™

Privacy Policy

The company informs customers through the Privacy Policy about how the personal information provided is used and what measures are taken to protect personal information.

Purpose of Collecting and Using Personal Information

- Identifying individuals, verifying real names, confirming intent to sign up, and ensuring age-restricted service usage based on service use.
- Fulfilling contracts related to service provision, such as billing for services provided, delivering content, purchasing and processing payments, and dispatching items or billing statements.
- Delivering notices, ensuring communication for handling complaints, and ensuring accurate delivery information for item shipments.
- Providing information on new services and offering personalized services.
- Facilitating smooth provision of high-quality services.

Personal Information Collected

- Name, company name, email, address, contact number, mobile phone number, inquiry details, and other optional items.

Retention and Use Period of Personal Information

- As a general rule, personal information is destroyed immediately once the purpose for its collection or provision has been fulfilled.
- However, for the purpose of ensuring smooth service consultations, the content of the consultation may be retained for 3 months after completion. In cases where other laws, such as the Act on the Consumer Protection in Electronic Commerce, require preservation, the information may be retained for a specified period.

Procedure and Method for Destroying Personal Information

The company, as a general rule, destroys personal information without delay after the purpose of collection and use has been fulfilled. Information entered for membership or other purposes is transferred to a separate database (or, in the case of paper records, to a separate file) and stored for a certain period according to internal policies and relevant laws before being destroyed. Personal information transferred to a separate database is not used for any other purpose unless required by law. Personal information stored in electronic file formats is deleted using technical methods that prevent the recovery of the records.

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